به گزارش
خبرنگار علمی باشگاه خبرنگاران طبق اظهارات پژوهشگران کرهای، نانوذرات میتوانند بعنوان سوئیچ مرگ مغناطیسی قابل کنترل از راه دور برای کشتن سلولهای سرطانی استفاده شوند. جیون- سو شین و جین وو چئون از دانشگاه یونسئی، در سئول، و همکارانشان نانوذرات مغناطیسی اکسیدآهن دوپ شده با روی را به پادتنی که گیرنده موجود در سلولهای سرطانی روده را هدفگیری میکند، متصل کردند. هنگامی که این پادتن با یک میدان مغناطیسی خارجی «فعالسازی» شود DR4 را، که گیرنده مرگ سلول سرطانی است، هدفگیری کرده و مرگ برنامهریزیشده سلول (آپوپتوزیس) را ماشه میزند .
چئون و همکارانش در مورد اینکه چطور نانوذرات امکان کنترل گذرگاههای سیگنالدهی سلول را فراهم میکنند، توضیح میدهند که سیگنالدهی سلولی به سلولها اجازه مبادله اطلاعات را میدهد و مسئول کارهایی مانند تقسیم سلولی، رشد، سوخت و ساز، و بسیاری دیگر از فرآیندها است. همچنین، ماشه آپوپتوزیس سلولی را میزند تا اطمینان ایجاد کند که بافتها بدون کنترل رشد نکنند و سلولها سوء عمل نداشته باشند .
این نانوذرات فعال شده با میدان مغناطیسی " سوئیچ مرگ " سلولها را فعال کرده و نحوه رشد جنین ذرات شبیه ماهی گورخری را تغییر میدهند .
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S4cjRbVOJXavTcCgUCgUCgUCgUCgUCgUFY94+/cZsXakncE9tT6WilqPGb4Kdec4IRc8rnmewUHhG2/4vcsvLtjceFjtYd1YS49DU4XWUn51lkhdu0C1RlOFh//AK+2U5llQ3cNNGIUvpnIkoJKDwKyx52nyar0yYV7L/w+4KflXX8LuFeP29kCmUwhTHpCem9Zf1SkqT4bK8Nxwr5nd/2TXo5V9O6PCte1us5/Rurwpvri1es+z3/Ym1MJtXa0LC4UlUFhJIeUbqdWs3W4ojtUa+i07abKRek5rPaWK1ZrOJ7p+uqpQKBQKCt7A/uKR+9Mr/iL9BZKBQKBQKDwP3xfxL/lfMyNu7XiNTsnF8E6c+SWWXLf0aEJsVrT865sKiZThS9pfxdbqj5BCd1Y+PMxq1AOvQ0ll5ocioJJUlYHO3CoyYfU2MykHJ4+NkILyX4cttL0d5BuFIWLpIqcobVSFBQ99TM5l4UmHh02xkV3pZR1I1PPaB9Y0yjhqQg2DnG54pANjecIyozMBElNxOddSOBS0UN28hCEhSfgvUYTl2XiGGxdcmQ2gcRqeUAPjJv8pNMGSG3l2pLErDPiW/FdQtpx0BDaVFWnSuUnQ2kLCtBBuTfvqcGXs+KybGShpktJU2QpTbzC+C2nUHSttYHzkkf6xwqBuUCgUCgUCgUCgr85fpmaW08f7NjumptjsW+sFQcX36BbQO+57BQaQX62feckuKONacUy1ESdKHi2dK3HiOKk6wQlF9PC5vfh0rTKs2S7UxDTaW2gG20iyUIASkDuAHCreCPJUveNtSHuXDuOspUznYQ9Jxk1hRaeDzPjQjqJsbKIsL8udROs8kX7m9+PZVIx8paVl1CXmiCnm4jqhWkW0FQCw4m1g4k287hyXer0CgUCgUCgUCgUCgUCgqzX/uLdRfPiwu3XFNsfsv5LTpcX5UxUKKB/1FK7UCgtNBW4X+YmX/dWP/r5lBZKBQKBQKCv7/2m1u3Z2V26450fWDBbbe/YcBCkKPkCki9B8m/+APenEW7jJWPjsw9dl5QvNlrTe2pAvrJI5J03rDz+bTi6p2X7R/f8nbTqnZaKw+udmY2JjNqYrHRL+jxIzbKCrmdCdJJ+Ei9X4HLjkaa7YjEWhXdrmlprPo+VPfl7uc9h/eHlM29j38hhsy6ZEaUwlTmlxYGppYTcpKTy8ldtmytP3TEZ90ViZ7PSP4Wvd3n8Czl9w5eM5ATlA2xChPJKHS22SrqrSfNuVWTeukQrKc9/m4cfH9XYhcBMjJvAuY6UVOIcacWrphTJbIOq4Fx8FN3DnbqtNYzavZ7vwG+dW7M28dc/u6ZiY9noOztqN7ex/TVKkTJr6GzMkSXVO3WkG+gHgkalK8vfWXicOmiJ8Y62nM/WWH5HnzyL5xWtYziIjHRP1reeUC4vbt7qBcfJzoFAoFAoOq3G2wFOKCASEgqIAuTYDj3mg7UHGtGkq1DSL3VfgLc/koOQQRccQeRoFBSPfF7vV782TJwjD6Y85K0SYTq/M6rVyErt81V7XqJHzD/4G96IYXAn45iAwySfSnHm1BxQBIS3oJKrkWv2V5vyXyerh0i+z1nH1/ENGjRbZOIVZOwd2SJadvs7emnOa9KkdJWkA2Gorto0cb6r2rZq302ftmJ6Z+v9HO1Jju9+zuI/KTG0tuw84/H3CtiLjJ/EOQkNr8OvprBsoKX4bc+fCsfyHxsb/HNfLy6dsxiO/wCT6f4PkU/hvG2tZ1648o9LTb2z6w9s2xhX8LhY+NfnO5FxnVqlvgBatSirkOwXsK18XjV06411/bD5/ncmN+2bxWKRPpCUrQyFAoFAoK3sD+4pH70yv+Iv0FkoFAoFANB+dmchSk7ty0afqTLTOkCRr87X1VXveqrOmXxjMVCShQNxx40H19/D0qbH91OCal6gSl1bIVzDKnFFHPstWS23F8Il6q0vUkGtVJzCGtmpyoGHnTkgFUWO68kHkShBUB8oq4oWUlNQdvxML0vSnMiUY7pFZRr6wJkuqWnxCzfUcJHb8NbJpiMM/k28r+XP7OchEZdU643FjrW0FrK18EJ1AauQ76TSCLINh/CwdzzmfVzS4/Ux8VgJabUGXZDbyys6hcBRCAfiqPDqny6JfKwozkLIRG46n2s4sNzkaxoaCmQz10oPLQG0myeN+NTOtHmldqOPR8y5Ecc6ypEFl6Q7y1yI9mHHbdhcSUX+CuG2mHTXbKQee34HnAxExamQo9JS5MgKKL+EqAjkA258a5Ojp1/eF/2eJ+1Sfu9A6/vC/wCzxP2qT93oHX94X/Z4n7VJ+70Dr+8L/s8T9qk/d6B1/eF/2eJ+1Sfu9BoZ+T7wE4PIKMXHt2jOkLiyZRfB0GxaAj8V380d9Bi91Un3oP7fbXv+NDjztKeiWFH0hQtzktpBaQv/AGFfEKCuZ7O5dvcuWEWR6P6K8F6NKSHSEBKepcE9PS3awtxuaDe27lUvYSI8kaQ4lS9PcVOKJHxGt2uv2wz2t1SPrDy1fwR5OFZVtlKnnFWbbBWs+RPE08DyeTe66e4Nw4h6y0Kec0rQpaDoDkjqBJbHFFkulKbc+3jXnNL6ToFAoFAoFAoFAoFAoILduWmRYjGOxigM3llmNjyRcN8LuyFD9hhu6/KbJ+dQSOGxMPEYuNjYYIjxUBCCo3Uo81LWe1S1EqUe0m9BuUFbhf5iZf8AdWP/AK+ZQSU7c+3IEhUadlIkWQixUy8+22sBXEXCiDxoN999lhlx99aW2WklbrizZKUpF1KJPIAUHZC0OIStCgpCwFJUOIIPEEUHNBqQMvi8gkKgy2ZKVJK0lpaVXQFFGoWPm6kEX5cKDOJUYyVRQ6kyUoDqmbjWEKJSFFPOxKSL0FK94qd1IJkYXEnJhqOpQJdQlCFjVf6skLWocCEgeLlXy/zHw1uTyK7J+7VWv7fr+O/5Pf8AhrcfHjtv4Zt7T1j8+0f+GL3W7zwWRx0bBt5V/IZliOZElUpBbWbr8YSOVm1K027BX0XD1Y0Vmv7e35fRn+a0WpyLZpFIz0iO2PSf17rRuiHIkYd8xI5lTWQXIscLDWtwDgnWq4F6wfMfF05mnwtnMTmMe7JwNsU2x5T41npM4z0UzY25c/kdwvwRi5MdEE9LMGU+2tLKykqSlGgnWrzbWHImvH+H+N36ORM+dra8YtFvf093t/K8PTr0RfzrM2608YnrH19kL7/HswzOwLkOaxCZQ6FCS4rSuM4HE/X8ATpt3d1fe8KIxOYeHxcYl7Eg3Qk31cB4hyPlrz2RzQKDz3cc5GK3zI3M44pELDwokXJgElPoktyQpTmnvbdQ0r/ZvQaGMyE7CKza5T7kbKZh+BMULNrKH5rax0R11IaQG24+i6jbw8ieBDp+f9ySI+LZbmxo86cy4YzmllTLzjM5UZxTqlLSlKQ0ErT0z4lE2uBpIS6tz7lakvzA63JitZGdjmsahmy1iNFefbV1QSrqKWzp4C1jyvxoIpe4dxZPCsPvZViM16ZiHxLaVHWpIkP6XW1oacWEs306Cs6jxSb0EqrOy28o9j2pkbCsvzsgXcgptJ1LjJYKGz1CEa3A6pSieOlBt3gJDdcd6Xk9nBMlBZ9ZFxwdNLiHSiE+4lQCibeadJHK9+ygr+P3dnE+q4kJEWIw3DgPhhSmWGnhJdUh0DqrCwlCU2R0wfHz7qDUy+ZktbdymKE9nGRRDzUouupSpUhXpshvoo1kAaeGq3i8SeXaHpuI/uqF2fUNcP5goNugUHmHvRVvCMJ8rGY1bsRDadWSC0LLDZA1rbYB1qUjxdlu2vkef8JbZy7b7/frxGI9v09vX9X1fwc8a3jW94i2f2+8+kTbt1/9IZ/fGMaiJfwq5eci4yI2rN5EupZkJFglDxbcCSsL0m9jwp8n/wBci1o5FL3r516zH4iXTj6P5NttWzx1bPP7aYmY/LMIGbJyOS95O0X5m3FqmOLjusqkFS9cUnV1XChRb1M+JSb8RYXr6r/r2ndq4M13XzMZxPrj0ebz9eulrRS2cd8RiM/R9DV0eEUCgUCgUFb2B/cUj96ZX/EX6CyUCgUCgUHjvvb/AIfcHvCevOY+UcTnHAPSHQnWy/YWBcRcEK/lJrle3inKgYb+GVuLI9L3NmBNjseJMSM2UJWRyC1qN9J7QK8j5P5GdWi9q/bMR37u2ivleI7vY9rZnGSFP4mIpKXsR02nWEp0pQhSfAE+QAWryvhOTs28ettk5t7+8NvyXBtp8b4xS/b9O66QlEoFfU6J6PLcZiD6wxM2DfSZTDjIUewuIKb/ABXrQPNoeUU9GbcdGh8AoeQeaHUHQ4g+VKwRXr1jyjLzrTicNbNZzDQIqJ+WdQzHiOBxD7gUQ25pKQrwg2NlEXqLRERmStpnpDFt/d+FzsZ6fiHOtG6nSVK6am0uLQBfSVBJWE3telMW6wm0zXpKV9P8tW8FPNL7HSuXmp88X6ERlENKuwurV1XR/NT0/lrDyp+7DZx+2V2rK7lAoFAoFAoFBUtxe72JmJy5QkmOXuLydBUeICVaSlbfBQSLpVqTfjbnQVLMNwNvz3IEF9EiGlailpCrusLUdTiHCqyT41E3Cri9iK2aN8RGLOGzXMzmGB3K9J9MVbbqZixduIWnA8od6W1AKI4+dy8taf5KYzlx8bZxh2yPpUXFycnkkhiPGQVx4RUlS3nx/RdUpJSlAXY6QTe3HhwrJu5Hl0js769eOsqJ7tozjm6cGwi6xHebUq9uA1EqNilJGoJSbp4Ht41kdn01UhQKBQKBQKBQKBQdXHG2m1OOKCG0AqWtRASlIFySTyAoK1tRt3LTH92SUlImo6GFaUCC1jwrUlZB5KkqHVV/J0D5tBZ6BQVuF/mJl/3Vj/6+ZQRm4c5h5m5k4jJOiPjcapp+Whxtf9rkmy2GhZJCmmuC18eKtI7FCghslP3NMmZ+G9JIUW8mz6r0urUuKGFiKW2wzoSVeFXU6p1XKedgA5hzc6uKxExGUnPQHV4pl2etpJW046paZaGipoJsGkoJ8JCFH4qDcdyeVkbv9Xx35jcXqSIUtlalKV00QlqQ+EhnptBTqUlCy4So9nYA0sb65x21IEZEx2GlnB4lRkyUqSQtTq+syp1DS1t+ABF9J0cDag6uKzUsSczEenw5MbBNrY81xTzzMqRp1rLSeqlQTcDSnUlQJFB6ipaEJ1LISkcyTYVEzEd0xGXg3u/mY6J73NwHHYpaSpp4KeeUsiMesCUJB4aXTx+LhwrZztvjx6zEx/q9K2ubViLS9MyMrIuxn1tOf2gNrLIUdKAvSdN+wC9fPRsm1o8pnGV411iOkPPvc7KzpXuF6Y6GnHZiVqYS4lbocKTrWspJ4K4afgNeh8lqpptH8WY8szLvu2ztrWL9YpXxj8mH31RWZ8zajk4F1DuRbhyAFFOthxSVFBt8fGtHxXJvi+fSuXCmuK5w9kj5eLYNqSWQngBzTYfBWSnKrbv0Yb8e0fVvocbcTqQoKHeDetMSzzDtQdVNNK1akJOsWXcA3A7++g6PxYr6FofZQ6hywWlaQoKCTcXBHGxoInKbPxGSefceLraJbKY01hpeht9lBUUocTY8PrFebY8aCYSyykAJQkBJ1CwHA2tf4bUGIY7Hhp1kRWQ0+Sp9sNp0rUeZWLWUfhoOz8KG+2Wn2G3WioLKFoSpOocjYjnQZShBKSUglPFPDkbW4fFQYlwoa1tLWw2pcc3YUUJJQT+wSPD8VAchxHdHVYbX0lFbepCTpUeak3HAm9BmAAFhwA5CgUCgxyigRneonWjQrUj9oW8346mEw+TmHW1YfdLOEiKZZcdY9IekurBUyFLIigqAv01ALtzPb2V6u/VTZFaX6xMen+Xt6d19WyuyJ+6v+VlxTWSme8PZjUnKqmIZx0fJKfbJIWY6SnQlRsdKtFiSO+s1+TFNF58cYt44cra8xPvL6AZzcVfBYU2fLxH6K8qvKpP0efbjXj6t1t5p0XbWFDyGu8Tns4zGHepQUCgUFb2B/cUj96ZX/EX6CyUCgUCgUGKQjUgiueyuYEHKia9Tak6kq4EV43J41dlZpaM1lel5rOY7w8fhxN0ZvfOeyGz5iInq5KIZcfIU29pNijzVAXUgniP9NefweFGmPDV2j3fd7t3H08TVTl18v5Pu6f7fr3+r03G5zdOJ2inKbmiMImMSUInJYVZKIinUtqf4FYuhKtZF/NFfR8WLeP3d3x3yFePG2f8AjzM68eq6VqYnnXvEwScWJG5IjjbbCyDkYa1BBW5wSlyPfznVcElv5/C3i87VxuR4dJ/azb9Hl1ju82dlScw+uLk0rgQEkpXh3gWpT4//ACUHSpDZ/wCWPO+cfm16NMbe0/b+O7BeZ19+/wCOzewcWHhMTHxkMaIsUEIvw85RUSfjNdqafGMQ5W3+U5lMYSPlNwSfRsQNSAbP5EjVHYHadXJxfchJ+GwrPv5FaRiOtmjRptfrPSHreGxEPEY1nHxAekyDdajda1qOpbiz2qWokk148zMzmXqRGIw3ahJQKBQKBQKBQcKBKSAbEi1xzFB89ZKOrES5bGRBjyWHilE4AqIULaOPEi48Wk8FJPb4qBid+4mDPkuTWlmUhAYjrYIUwlgWXob6igpKSrxfs8rUELuzfEnOOpixm1BAVoZjoJUouG9gSLXUrSUgjlyPbqgej+5jZT0NKsvLF1AqDJ4aS4RoOi3DS2m6bjgVFXYkGpHrNAoFAoFAoFAoFAoKvudSs3k2Npsk+jOITKz7ib+GGFEIj3HzpS0lJ/6aV+SgtCUpSkJSAEgWAHAACgUCgrcL/MTL/urH/wBfMoLJQYZs2JBhvTJbqWIsdCnX3l8EpQkXJNBEQ94Y+S6phUWZGkllciNHkR1tOSG27aiyFecoahdBsoX4ig1m/eBiFxchKXFnMsYzUJa3Yy02cQUgtj9pf1gsBQSeM3HjcgiQUFxh6IsNSo0htTTzaikLTdCuxSTcEcDVbWiO61azPYkZjmGE/wA9X6qzX5X/AMtFON7o51155Wp1RX5Dy+Ssl7Wt3lqrWK9nlW0o2Vc98O4EyZhU3jWCC2LjqpklKm9QP/LFexy71niUxHf+2P8AVftD0qc22qDJDoUWi04HAjzinSb6fLblXj64nyjHujLzD3HnHKl7iETrPq1sFU10ghSLL0t2AACk8Se+9e181Fvsz9ei09npk7EY2eWDOitSTGcD0fqoC+m4OS035KHfXi0vaufGcZRltaKpgy7NqdaVqbUUnyVelrV7SpasW7pCPl3E2DydQ/aHA1qpyv8A6Zr8b2SLMlh4XbUCe7t+StVbRPZmtWY7tDMfmjqt+phBLWk9b0wvBWq/DT0xa1u+rKo+/vG7sP8ALK/VQL+8buw/yyv1UC/vG7sP8sr9VBV/dwr3wHcGWGeTE/Kfpb/q5T/U9M0azbo349HV5vW8Wm1uFB6ZQKBQKDqtxDadS1BI7zQaEjMNpuGU6z+0eArPfk1jt1d6ce09+iLkvyZIIU4QSCE25AnkbVjvutbv2a6aq17PmyWl5eI3LOzD7rqGsgmAnoKUlKZDQWS6rssseHjX1lbRN6RXp9uf09v0dsYxEPXNmbSxamMBuX0d6DPZxTcREIru2htQvxChq1cb3vXz3L5Fs315i1ZvnJMrlorzsIy7I1oN0KKT3g2q1ZmvZFoie7ej5aSiwcHUT3nga1U5U/7ma/Gj0SUefGe4BWlX7KuBrXTZW3ZlvrmvdsVdQoK3sD+4pH70yv8AiL9BZKBQKBQKARegwLjBRvXK2rI1MdgcZji8YUVqN6QvqvhpARrcItqVbttVKaIr2ddu/Zsx52m3jGIz6Q3X4seRGdjPoDrDyFNutKF0qQsaVJI7iDXeIw5K1Dxm+cXGRjIEmBMgsANw5s7rekttJ4IQ6hvwvqQnhr1o1dvHjUjcx202m5zeUzEpeYy7VyxIeSEMx7ix9Gjp8DXDhq4rPao0EnkMRisk2G8hDYmIHJL7aHAL92oGgi2vd/sltzqJwkQq5jU0lQ/+FVxVpvafWVYpX2hOtNNMtpaaQlttAshCAEpA7gBVVnagUCgUCgUCgUCgUERndq4XNp/tzH1unQH2zpc089JPJSf5KgR5KDz/ACHuAxDzi1R5pQlRJ0qQb8RbmhaU8u5NBKbf9zGBxj5fkumSo+clCS0FXvcKUVLXY34hJTftoPQWmm2m0NNIDbaAEoQkAJSkCwAA5AUHagUCgUCgUCgUCg0c7mI2GxMjIyQpaGE+FpAutxxRCW2kDtW4tQSkd5oNPamHlY+A5IyJSvNZJwy8o4nikOqACWkH/lsoSltHkF+ZNBNUCgUFbhf5iZf91Y/+vmUFkoIfd2Kfyu3ZkGOtCJCwhxgu8Gy4y4l1CVkfNUpGlXkoIZU7IZbO4mXIxjuOYxJefdL62VqcfdZUwGmuity6AHFKUs25Cw525W3Vh1rptKJymMzMnbu54DTWh3JznHooStIUptXRAUFXsk+BXOuM75y6xobW3cTLxr2TZklclTsjrNZV5zqPSG1JshLtzcLYA6fABJTYjjeuN58urtrjCa01TC+XQraBsVVSbQtiUHjNpwIe68puNqS4uTlWmmno6gnQgNAAFPDVx09tabcrz111+lSZnCwJSNQ+GuGFcqF7pcRksbH3C1OiOxerln3Y/VQUdRpQFlpvzTXpfI3reaTE5+yF7yvmmvOwpk00wZNNMGTTTBlyAQbgkEciKmMx2ROJ7t2PknkWS4Oonv8AnVppvn1Zr6I9Eky8h1OpF7doIsa0xOWeYw71KCgUCgEgc6DA7OjN/O1HuTxqlrxHdatJns0nso8rg2kIHeeJrhbke0O9eP7tF1a1HU4snyk1mveZ7y0UrEdoYuo1+1XLyq6+Mu6bGxSbirRGVZeYbx92cyPszPQsF1slMzOSanqYV00FB6mpaUm6QQB317PG5sTtpN/titcLRfr1emRmlJjMpULKS2gKHlCQDXk2jqplk0VXBk0UwZNFMGTRTBlsx5shmwvrR+yqtFN9o79XC+ms9uiTjTG3+ABSruI/11rrbMMtq4QWwP7ikfvTK/4i/VlVkoFBGO7lwrWW9UqkE5AaNTKW3F6erco1rSkoTqt2mg3YUyNNiMzIqw7GkIS6y4AQFIWLpPGx4igzUCgUCgxMy47zr7TSwpyMoNvpHzVKSFgH+aoGgy0CgUCgUCgUCgUCgUCgUCgUCgUEJsydLm7eZkS3S9I60ptbhABPSkuNjgLcggCgm6BQKBQKBQKBQKBQVZP/ALi3UVnxYXbjhSj9l/J6bKV5UxUKsP8AqKPaigtNAoFAoK3C/wAxMv8AurH/ANfMoJyT6Xx6RGnyed+mud/L0dKePqjnA4o/WEk9yqy2zPdpriOzr06r4p8jp08TyOnTxPJjkMrU0Qjzu7vquykzHReloz1RxSUmyhY9xrHMYaYl2abcWoBAN+/uqa1mZ6ItaI7pPp1t8WTyOnTxPI6dPE8jp08TycpZUo2SkqPkq0a5lE7IhsN411XnEIHymuscf3cp3+zYRjY6fOus+XgP0V1jVWHOdtpbCGWkeYgJ+AV0iHOZdqBQKBQdHUulP1SglXeRegjZDcm/1xUR3801nvF2ik0YemK4eLt5OenTxPJqTGHSQpIKkgcQOys+7XPeHbVeGppVe1jes+HfLahsO69agUot29td9NJzlx23jGG5060+Lh5OOnTxPJz06eJ5OOmKRTKJszNwXl8k6R3q4V0jRKk7obDeMbHFxRPkHAV1jRWHKd1pbCIsdHmoF+88T+musREdnOZme7LUoVvYH9xSP3plf8RfoLJQKCsY/FZIb0zc8vPsQnExA2yEtdF8pZWlRKlIU54SR5qhQVlH5ogYUY9uNkA+9jMQ3CQwhwpadaWoSwVjwNKCbarkFQ5XoM0hrc/WlKjJyQzGrKenLJd9FVHLb3oIj6j0dWosaOn4h4tXG9B0y2K3KwvHsIm5BuP6AhTcpLcqa8MipzU8p3pOtgG2nSHR0rahYDhQZJre5m52eRjxOkrkIdcEkpksLZSl9u7DAdUYrilMlYZWyARbxcTeg4zcaa6zCRiVZSJhCmUHFOM5F+QmUQ10F9PqtSQgDqadV0auY5Gg3lY7cMzIxY0x2cqCucn0pxC1x9bAxIvq6SvAhUrmlKvPoJba0XciMfjFTZZS0yypuVEkNFcla0qWELL5cFvDp5oJPfxoLHQKBQKBQKBQaeZy8HDYqVlJylIhw2y6+pCVLUEp52SkFR+AUBvL492REYadDipzC5UVaPEhbTZRdQUOH/GTag3AQeVBXHd0ZZ3ITouKwjk9nHvCM9J9IZZSXemh1SUpWdRCQ4BfvvQPX27vZhf22N+ugevt3ezC/tsb9dA9fbu9mF/bY366B6+3d7ML+2xv10D19u72YX9tjfroI3b0jeWKxnobm2y6fSJTwUmZHA0yJLj6U8e1KXADQSXr7d3swv7bG/XQPX27vZhf22N+ugevt3ezC/tsb9dA9fbu9mF/bY366Do9uPdjLLjqtruFLaStQTMjFRCRewF+dBJN7kxioWKmqUpEfM9IQ1qTw1Pt9RtKyOCSocBf51hzIoNmDlIc5cpMZRWIbxjPOWIT1UAFaUqPnaSrSbfOuOYNBt3F7dtAoIPdmXlw4bMHGEeu8q56LjQoXCFEXckLH7DDYKz38E/OFBv4XERMPio2NiA9CMjSFLN1rUTqW4s9q1qJUo9pNBu0CgUCgrcL/MTL/urH/wBfMoLJQdVtNrHiSDUTESmJw11wRzQfiNc51R6OkbfdhVHUnzgR5eyuc0mF4vEuOlUeKfI6VPE8nBZB5i9PFPk56NPE8jpU8UeTgtgc6eJ5O6IriuzSO9X6qvGpSdrOiE0niq6z5eXyV0ikQ5zeZbASlIskADuFXVKBQKBQKBQKBQKDC5EZVxA0nvT+qqzWJWi0wwKiOJ5ALHk4H5DVJ1LxsdOmm9jwPceB/TVPCVvN26Hkp4p8joeSnieR0PJTxPJ1DWo2SNR8nL5amKSidjKiETxWbDuT+urxrhSdkthtlpvzUgHv7flrpEOcy70CgUCgrewP7ikfvTK/4i/QWSgUBSkpSVKICQLkngABQaYzOHMVMsTo/oildNMjqo6ZXy0hd9N/JQZXJ8Fp9uO7JaQ+6dLTKlpC1KteyUk3JtQdI2QYeZU4v+zlPUKm3VI1BDaygrOlShpOm/P4bHhQdlZLHJkCMqUymSQkhkuJCyFmyfDe/E8qDSmbp2/EhmY7PYMZL7cVbiHEKCXXlhCUqIPA3Vc9w40G+mbDVJMVL7apIQHCwFpLmg8lab3t5aDRh7ix0zNSMVFcS+7FYbfedbWlaB1HFt6DpJIUC0bg0EpQKBQKBQKBQRG7YEuft6ZEiI6kl1KQ2i4TchaTzNhyFBVsxs/cLc6axiNPqlyBMMEBzpLZkSn2FuxUkcUtuhpZQoeYVEctNBObQxj8STlH0QVYnFyVsmFjFFsFCkN6XXNDKlto6htwSrjp1HnQdtlJuxmHe13LziT/ALDxa/8Ap0GxvWSuNtHMvNrU04IbwbcbUUrSpSClKkqHEEE8DQUbMZrMpwTGGE15GS246l7MyUKUl11mG82I+tQ42loWlxXeAsUE9N3zko+ZfYjx250IJmoY6aHGj6RCaLha6zh0OEqQpCtKLJPzjYig14m99xyYzDzDMN9ifMjQ8dN0PstOB9lTzruhZKyG7aRbzj2jsDhzfm49aIkbGolZCO3IdmIZQtSHTHmORNDRKk9LX0FK1L1BNwOPOgzRsrmEzZgyDqZDI3C3FhJaU60ppsspXpVpXZYFx4TwJv5KCc2rlMxlsexlJYjIhz2ESYbLOsutpcGoIdUolKyEkXKQnjw8tBTMRn5+EwispOQJsxQzcxRaceQFqYltsoStClrSeYAUR4Ejw9twkpe5swyuHNysVbIx8iWuyEqZElpvGuvcGlrWpNlAp8R5i48gbm2puZk7vkqybrBLuIhvtMRSvpth1988dajqVwtrAF7cqC4kAgg8jwNBS8FAXlPdPFgpR1Hl40NR030kPNJsyUq4aVIcQkpPYRQa2c2pkfU23ojMdx+FBbWMlBaDDy1vOtAB5SZKktOFLhWVEqvdWoUGJvFy8Lm4WWeYdMaLFaTk8jkvRnekyzGKFLakNr6yXNVgtAQUKN1Dneq3vFYmZ7Qvr12vaK1jNp7McT3j7k3DlW2trYUu4ht5KZWRk+AFsKGvRcpSk6eQuT5K8uvP2bbY1V+3PWZfQ7Ph9HH1zPI2Y2THSse/p+OjJufHe8iPu57PYNiLNjIjpjRmHlDWlvgt0JBKLFbg4nVc2T3V05E8qLzNMTX2Z+FX4+2uI3Tauz3jt9Pf/CxbU3JPyWLEnNQDhpXX9GSy8q3UcH7AVpVxPAD5L1343Iteubx4TnDJz+HTVs8dVv5K4zmPSPqmo02HJLgjPtvllRQ701pXpWOaVWJsfJWt5zNQKBQVuF/mJl/3Vj/6+ZQWSgUCgUHUtIPZY+SownLr0u6x+Go8U+TjR3p+SnieTjSP2Sfip4nkBlaufgHcOJp4nkyIaQjiBx7zxPy1ZV2oFAoFAoFAoFAoFAoFAoFAIBFiLjuNBj6Dfzbp/wBk/wCrlQOkvsX8oFRhOToA+eSvych8gqcIyyAACwFh3UCgUCgUCgUFb2B/cUj96ZX/ABF+gslAoIrdWKkZbb83Hx1JS8+gBIcuG16VBRbXp46HAnQryGggJmDyr78PIjAwvqW5cd3ELeR0yZIaCZGsNaNQDJQoab6FcD82g1IXu+mxo7oe9HkS0owqGZqr67YxTZeOopKk30K08fhoNFrAZ6fipEnFRmnG8tBykAekrXHLYkzXnWnikoUpSFIcva1+XfQYWY0pO83P7KHS3OKoLKkK6zUj0IRjLd1NeKNwunS8OBHC9kgNqLsncXok1+XEjvSnE4xSYy3Wyhx2BKU86AG2W22kqQrS34T5aDYc2LmHctkVqKk+lOy5MPIpkBPQXLiqYSktBvqKLWrSB1NNgDzFqCU2lgMnCyzk2Vj4uNYGPiwG2IrnUuuOt1SlmyGxpIcGnt76C20CgUCgUCgUCgUGvkITc6C/DcW40h9Cmy6ystuJ1C2pC08UqHMEUFD9zuy92beiZR3dOVfyU9+bITE6i7tpjB1RDwQmyepIV9Ys2vyFB6BJjR5TC48lpLzDgstpYCkqHPiDQYHcRi3VyluRGVrnIQ3MUpCSXkN3CEuG3iCdRteg0J2zdvS0zVJiNxpc5DiHZzCUofBeTpWpC7GxUD4u/tvQYcFsvGYt1x4hD7q1NLQlLLTDLamAtKFtstJShLlnCCvmRw5Cg3pm2tvzen6Xjo73RW443rbSbKdVrcPL56/ErvPOgyjC4kSnZYhtCS+42887oGpTrSdLaz/KSngDzoOIGCw2OffkQYTMZ6SbvraQElRJKje3lJPw0HcYjFBsN+hs9MJdQEdNOnTIVqeTa3JxXFXf20GGDt3BQW0tw4DDKELLiQlA4LUgtlXw6Dp+DhQc4vb2CxJWcZAYhqcAS4pltKCUpJKUkgck34DsoONw4lzLYWXj2pT0F99siPNjqKHWXRxQ4kj9lVjbkeR4UFU9zO09ybe2g03uaa7Lzb6lKfQ4vU2w2lSg200keEC3jJA4k8eygvlBSJ26MtL95DG2ICWl41iOpzMB1GsKStN7A9hAKQP9rjXm35F7ciNdf2xH3Pc1cHXThTvvnzm32Y/H5/0XGHDiw4zcWIyhiM0NLTLYCUpHcAK9CtIrGIjEPG2bLXtNrTm0sjrrTLS3XVpbabBUtxZCUpSOJJJ4AVZR4N7z/eNiN2ZOHtvbUdzKzIz3UE1gkIR2KKT2ju4XJ5W7cPP438uvp+6vWHrfD8//AI+6M/sv0t+T0T3RLVJ2sma/rMxxXReU4nR4WBpbA4C40m9+81bg7526ome6ny/Ero5Fq1/b3j9fT9F3rY8woFBVpS/V/vIhuuHSxnMcqGhXZ6TBcU+hHwqafdI/2aC00CgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgUCgwZCdFx8CTPlrDcWI0t99w8kttpKlH4gKCF930OVF2fjvS0FuXKS5NkNngUuTXVyVIPlSXbUFhoFAoIxrcWMcyzmKJdbmNtreUl1l1tBabUEKWHFpCCm6hxvx7KCuxt/TXdt57KOxEMSMbHXkMe0oqKXoLjanIry+RBX01BQHIigsWL3Hickl70d1SFxykPNPtuR1p6g1IVoeShWlY802sfioIyHvEK3LnMVOaRGh4xtL0WZqJDqG2kLlahbwlkvI5dihQQ8b3lZE4vG5GXiw0h+ZLZyTKVkuRoscLWl7TbxKS3oW4nsGq17cQ3s1vSVGeLMRUNpCskzAbmylnoBt2B6Z1CUlPM+EeKgm9r5lzM4RjIONJaW4pxB6aitpfScU31GlEJKm3NGtBt5pFBK0CgUCgUCgUCgUHCloSLqUEjvJtQa7mTxrQu7LZQBz1OJH+k0GqrceLJKYylzVj5sRtTw+NaAUD41UHRWVy6z9RiihPYqS8hv8A3Wg+aDEcjuBs6lR4rw/5KHVoX8Slo0k/Dagk4E5idERKZ1BC7goWNKkqSSlSFDsUlQINBsUCgUCg0ZmcxUNzovSE9c8o7YLrv/y2wpf6KDE1ubAuEgzW2Vjm3IPQWP5juhX6KCQafZdTqacS4nvSQR+ig70HVx1ptOpxaUJHMqIA/TQedxpO1ttbszW58puKD0slpaaYSsKcRYjw2SVFR8NrAVg06IpvtabRm3p6vZ5XMnZxNeuKzFaT+70mUTuT+I3bsNtaMBj5OYkDzXVpMSNxFwSp0dQ/E3xre8Z5e7k/eh718qvHOSOpGQr6zGwwpnHxxfgqQ7clwix4KUT3JFQPdvd17r8DsfHlTdpGTcTql5BYt2cUtj5iBTsmIyye7HdGX3HjZ83IFstty1MxC2jQOmlIPHib+dWD4/kX21m1vfo9n5rha+NetaZzNcz+a5V6DxSgUERujAJzmKMZDxizWHEScdNSNSmJTJ1NOAHmL8FJ+ckkdtBq7a3WMg6vE5VpOO3LFTeZjieC0jh6RFUbdVhXYocU+aqyuFBYaBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQcKUlKSpRCUpFyTwAAoKVJlDfU1EGD49nxHUuZLIDzMg6yrUmLHPz2ErSC84PCq2hN7qsF2oFAoFBV3NoZJ4ZpD+TQpOa1IefTHKX0Mk6UMpWXVJ0IaKkiyBxUVc70GOb7t8GpEhGKQjEolwJGNlJjtJstt4DpqIuOLKgSn4SO2g3I20Yz7sqRnxHzEiV0QUORkhhCYwX0tDThe8V3VkqKu3sFBq5PYEWf1CuWttT2QVNeUhIuth1tDL0Q8f6NxtsJUaDbjbTaYygnekqUBNkTeiUi15LAZUi9+QtqoNGF7usdEWlCX1Ow2sn6zZiOoStDaREVFTGTf8A4aNWpF+XBPIUFtAAAAFgOAAoFAoFBwpSUpKlEJSkXUo8AAO00EM5mpctpS8W0BGA1esZAV0ikcdTTabLcFu3wpPYTQVR7dMJh4etMnMhvPMiVFcU6gdVkm10sMpWlPYbEE8eJvQVSf7zs2mW+mNOmNMIUSz1W4uooSnV4tTfb01fL/J4hpS/edupbBSrLvMBQsohMZtQ7zq6K9PI37vH+wNQQa94ZhR/tGYkSjpuEuPFROkKNv6BQGot6fJc9wJDXkblntvobTMWOqtDLax01qWtQQLpAaSbq1lQHwdyrhqSd2ZtoqByEhiQ0rQ40fqClfEqSr6xJSUOeEptfTx7agaxn7+ymhMJ7MzQbhIQ7JcuTwTxT4eVuSudzQSLPul97eWcSiR1ca1f6x+fLURbyIaW4o9/Oguu1Pc/tPbE2Nlczlnc3mWFBURoKKUB0G46UZCluOqB5aifgFSPXsDFkR4BMlPTkSHXJDjQN9BdWVBFxwukEA27aCRoFAoKlnc1HSw5LnvO+hF5ceDjYytDklbRKVqWoFKtOpJ4agkJ4qve1BAqybc6FIOOjnHNRGyH4iHfRiHHT9S9rjpUXk8CkJ56uw8KCt7xHvhVjkMMY1nLIXoJjxXGY0kpSQNbjD5f8Oq2rx8+abUwZRMnY+/YuPanzccywVaUuMsyYzq2ipVk9Q9FCbX0i4KrEkm41XmKzKJmIaTuyN43UtUIJJvcqlsp495ISb8r/D8d7/xWc43VQk7Y+US2sON4xD6rAJcl9ZRtc8EpZUrnp+IW7b1Sa4Xi2WGBtHcq8fNkIxiBFhj64xgVpRc2T9WQFcBbsvw1EC9z4/P1WpeN9IzMd/yfTfD8jXt1W4m2cRbrWfafx1/qu+1v4dUTVR5G68y6rW2h5eGi/UL0qtwecP1gFxZQQE8e2vUpbMR6T7Pn9muazMd4icZjtL27CYLDYLHNY3EQ2oMFkWbYZSEp+E9pJ7SeNXc1Y3Rvnbbkh3bCHJUuZNacac9WJDzjZKbae7Va/wAHbasG7la7W/hz1t06ej2ON8fvpT/kzWPGkxOLev4/v6Om05Dm38HHxMHbmWfQzqKn3ERGS4tRupRC5KbVo43HjVSKQx8/mW5O2dlumfT2SytwboV/RbWkjyvSoaB/uOu13Y3Kcpvhfm4CI3/6uRI/q4zlBwp73hL82JiWfhkyXf8AQw1QAz7wl+dMxLPwRpLv+l9qg15ez5+YdZG5JkSfGYJWymPEciPtOkcHGZKZC3WlD+Ta9ByNrboi2Rjd1yegPNayEdiYQO7qAMOn+comg7epd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igepd++00b8MH3igHCb9It+Z448oxqb/Fd8ig6HYTc8g7kyszPIHEwnihiESOPijR0tJcHkdKxQWhpptptDTSEttNgJQhIASlIFgABwAFB2oFAoFAoFAoFAoFAoFAoFBF7gSHWIsVf9BLktsyL8i3xWUHyLKAg/DQeXZjOT8i5IyapTzATrVBbacWhLKEkhrSlJAKzYFV73PDlwoJqFO24p6W/JhoV00MuBhLQQyqyEdZ4IslDmlbxsTfgPD5elaZhW1sO+3Np7ChzZeQb29jmM31VNTn0MJIKxY620q1BtLiVBVk251aNSvm0n2sb+YJ8TB4ESG2g0XlMxwIzchQUpxKXAhSQvToKkp5Hy1PlFeilqTact4Y3Mq4Kiux+5LUMuf7xeaH6KpOxaNWGQbPmzUdJ+JJfbcFnETHI8aOQexSI/XeUP5OoX76pM5dIhPo2epUj0p6faUoDW6zFiIULCwShamnHAlI4C6ifLUJbv5XgLFpL8yVfn1ZT9j/MQpCP0UFZ9Y7EQnOOjDJfj4RLZXJW2h1L5cUtuzJcJ4JcaUhSlWTcHjYXoJrb07G6MkGsQjFzcaQiWw2lqx1NB5GlxoWVdKhw5ju5UG9t3cmLz2PZlQ32lurZZekRm3UOLZLyAsIc0ngezj3UGzFzWHlynIkWdHkSmRqdYadQtxIB0kqSkkjjwoNPD7kjZTL5jHx+mRh3UR3lpdStZdU2HFXbSLoSnVpuTxIPDhQTFB5fu3HzosuNraUtuOl9ptV0pStt13qoWhSylOr5i031XAIBFBoxcXnYseRKm/8A6z0pDbkBCylIcVGc6iWnHFizZN9QChx+BJvMT1JZ2dxPu6pzjh9KhOxQ4k3GlT7bbclmx+aq4WAOF7EVsrSJjMM03xOEzIRkNyuqwsOQuJGSUOZPINBJW2hKgtDLWsKT1HCOJI8KePMprnu+3p6ra/u/JJI92O2L6pHpMxw+c5IfUtR+Ei1Z5mZdorENxjYW02fNg6h+ytx1aT8KVKKf0VCU3GixorKWIzSGGUea02kISPgAsKCpbr92kHO5P1uzkJWOygSlAkMrJTpTyGm4I/mqFefyfj67becTNbPZ4HzV9Gv+Oa1vr9pdoOxcn+XMjhMtnpOQE5SS3LOpLrSU28KSpS+ZTU04dv47UvebZ9Tb8pT+am3XrrTx9PSf7QkdrbG27tlojGx/r1izst063lDu1cLDyJAFdeNw9emPtjr7+rNzvk93Jn756e0dk/Wp55QKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQKBQYJ0NmbFXGe1BC7EKQdKkqSQpK0nsUlQBB76CqN+7HErm+kTn3JDQWXBFRqZaK1G5UpKVEczeyNIv2UGhujZGV9HD2NWJLrbJiJGgJeMbgUtrJXoXbTpCgkKHPxcQb0v4yrauWhioW658+UpvGv48yOknrTEpSloIRZSyAo6yCqwCeduJArVbfSIzDPGq3q9FxOLi4vHswYwPSZHnKN1rUo6lrWe1S1EqUe+sUy1NugUCgwT4plwZEUPORi+2pr0hghLqNYI1IJCgFC/A2oKe7sHJss5RiHk1LjSoUOHGjPJaQjpxXFqW04WGm1JQ42vp3TxspRseFBIba2xJxkfKtpYj46NPIMXFxFqWwwrp6VrCihqxcVYlKUAC3eTQdcHtfIYdWOWwIylRMXExjqAVISS04C6tNknhpKijvVztzoIfau3twCPBlqiR4isW5lXIbbinEuvuS33AjrjpDpNkHWq2vV4T2UFnxuKyECfkpCAytGSnpkuXUoKQyIrbRtZPiX1GuXKx534UE1QKBQVib7udry5Lb62n2y3bS2zIebRZKtSRpSoCyTxSOQ7LVat5r2lW1YnuncbjIGMiJiQWUsR0EkITc3KjcqUo3KlHtJN6iZytEYbVQFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFAoFB//2Q==)
رهیافت این گروه براساس کشف اخیر یک گذرگاه سیگنالدهی آپوپتوزیس بیرونی (که مرتبط با گیرندههای مرگ در سطح سلول است و روش مهمی در توسعه داروهای جدید سرطانی است) استوار است. در این تلاشها، لیگاندهای بیوشیمیایی که قابل اتصال به این گیرندههای مرگ هستند، مورد تحقیق قرار گرفتهاند. متاسفانه، این لیگاندها دارای نیمهعمر بسیار کوتاهی در پلاسمای خون هستند و بسیاری از آنها قبل از اینکه بتوانند به گیرنده برسند بهسرعت از بین میروند. این گروه کرهای به فناوری نانو و روشی که در آن یک ماشه بیولوژیکی، بجای بیوشیمیایی، برای گیرندههای مرگ سلولی استفاده شود، متوسل شدند .
این گروه نشان داد که افزودن یک عنصر مغناطیسی، اجازه کنترل از راه دور و غیرمخرب فرآیند سیگنالدهی را با استفاده از یک میدان مغناطیسی میدهد. این قابلیت، اجازه کنترل مکان نانوذرات مغناطیسی در بدن و هدفگیری بافتهای بدخیم را خواهد داد .
گروه مذکور با استفاده از ذرات شبیه ماهی گورخری این کار را اثبات کرد و نشان داد که قادر به اعمال سوئیچ مرگ مغناطیسی در مقایس میکرومتر است .
شین میداند که این کار اولین نمایش امکانپذیری سیستم نانوسوئیچ مغناطیسی در محیط زنده است. وي میگوید: مطالعات اخیر فقط روی سیستمهای مصنوعی تمرکز داشتهاند. مطالعه ما بسیار پراهمیت است و روش موثری برای کنترل دقیق عملکرد زمانی- مکانی سلول در مهرهداران زنده مهیا میکند
وي افزود: این پژوهش نحوه دستکاری بالینی عملکرد گذرگاه سیگنالدهی آپوپتوزیس در سرطان و سایر بیماریها را مورد بررسی قرار داده است.
انتهاي پيام/